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近年来，对Ｔ细胞的活化及其抗肿瘤机制有了新的突破性认识，Ｔ细胞共刺激反应是激发有效的细胞免疫应答所必需的，Ｂ７分子家族及ＣＤ２８／ＣＴＬＡ－４等共刺激分子在共刺激反应的信号传递过程中起重要作用。本文简要综述共刺激反应信号转导形式，诱导细胞免疫，抗肿瘤及与电离辐射的关系等方面的内容
In recent years, new breakthroughs have been made in the activation of T cells and their antitumor mechanisms. T cell costimulation is necessary to stimulate effective cellular immune responses. B7 molecules and co-stimulatory molecules such as CD28 / CTLA-4 Plays an important role in the signal transmission of costimulatory responses. This article briefly summarizes the aspects of co-stimulatory signal transduction, induction of cellular immunity, anti-tumor and ionizing radiation