多年来的研究表明,细胞色素P-450依赖的混合功能氧化酶系有两个重要的作用。(1)生理作用:即参与体内的胆固醇、胆汁酸、类固醇、激素、维生素D等的生物合成与代谢。(2)解毒作用:许多外源性化学物(毒物、致癌物、药物等)都能经该酶系代谢成极性较大的产物,而易于从体内排出。细胞色素P-450是许多代谢酶的终末氧化酶,它以多种形式存 Studies over the years have shown that cytochrome P-450-dependent mixed-function oxidase systems have two important roles. (1) Physiological action: It is involved in the biosynthesis and metabolism of cholesterol, bile acids, steroids, hormones, and vitamin D in the body. (2) Detoxification: Many exogenous chemicals (poisons, carcinogens, drugs, etc.) can be metabolized into more polar products via this enzyme system and are easily excreted from the body. Cytochrome P-450 is the terminal oxidase of many metabolic enzymes and it exists in many forms.