本文对3例小儿神经母细胞癌细胞系,运用G显带技术,进行了染色体核型分析。介绍了小儿神经母细胞瘤及其细胞系的三种主要的染色体异常,①1号染色体短臂的畸变;②均匀染色区(HSR);③双微小体染色体(DM)。并结合文献讨论了染色体异常与预后的关系。指出了1号染色体短臂畸变的存在与否和染色体的倍体数可作为评估预后的重要指标。 In this paper, three cases of pediatric neuroblastoma cell lines, the use of G-banding technology, chromosome karyotype analysis. The three major chromosomal abnormalities in pediatric neuroblastoma and its cell line were introduced. ① The short arm of chromosome 1 was distorted. ② Evenly stained area (HSR). Combined with the literature discussed the relationship between chromosomal abnormalities and prognosis. Pointed out the presence or absence of chromosome 1 short arm aberrations and chromosome ploidy can be used as an important indicator of prognosis.