胃癌是发病率较高的恶性肿瘤,也是导致肿瘤相关死亡的主要病种。胃癌患者中将近20%HER-2表达阳性。HER-2在HER/erb B家族的活化和信号转导中起着重要的作用,参与了肿瘤细胞的增殖、分化、转移和细胞转化,HER-2过表达还与鲍曼分型,淋巴转移,静脉浸润,淋巴管浸润相关,HER-2过表达患者预后往往较差。目前针对HER-2靶向治疗的方法包括单克隆抗体、小分子酪氨酸激酶抑制剂等,都取得了一定的疗效,但同时也出现许多新问题有待解决。 Gastric cancer is a high incidence of malignant tumors, but also the leading cause of cancer-related deaths. Nearly 20% of gastric cancer patients have positive HER-2 expression. HER-2 plays an important role in the activation and signal transduction of the HER / erb B family and is involved in the proliferation, differentiation, metastasis and cell transformation of tumor cells. HER-2 overexpression also correlates with Bowman’s classification, lymphatic metastasis , Venous invasion, lymphangiogenesis, prognosis of patients with HER-2 overexpression is often poor. Current methods targeting HER-2 targeted therapy include monoclonal antibodies, small molecule tyrosine kinase inhibitors, etc., have achieved some efficacy, but also many new problems have yet to be resolved.