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目的:研究不同浓度益肺清化颗粒及益肺清化颗粒与吉非替尼联用对人脐静脉内皮细胞(HUVEC)增殖的作用。方法:以不同浓度益肺清化颗粒含药血清及益肺清化颗粒与吉非替尼联用干扰HUVEC。结果:高剂量益肺清化颗粒对HUVEC的增殖有抑制作用(P<0.05,P<0.01);10-80μmol/L剂量的吉非替尼对HUVEC细胞增殖有明显的抑制作用(P<0.05,P<0.01),且呈一定的线性量效关系;30、60μmol/L吉非替尼联合益肺清化颗粒高剂量含药血清对HUVEC增殖具有抑制作用。结论:高剂量益肺清化颗粒对HUVEC增殖具有抑制作用,且与吉非替尼在30或60μmol/L剂量联用下,具有明显的增效作用。
OBJECTIVE: To study the effects of Yifan Qinghua Granule (YPC) and Yifanqinghua granule (Yifangqinghua granule) combined with gefitinib on the proliferation of human umbilical vein endothelial cells (HUVEC). Methods: Interfering HUVECs with Yifan Qinghua Granules containing different concentrations of Yifanqinghua granule and gefitinib. Results: High-dose Yifei Qinghua granule could inhibit the proliferation of HUVEC (P <0.05, P <0.01); Gefitinib at 10-80μmol / L significantly inhibited the proliferation of HUVEC (P <0.05) , P <0.01), and showed a certain linear relationship between dose-effect and high-dose of 30,60 μmol / L gefitinib combined with Yifan Qinghua Granules containing serum on the proliferation of HUVEC. Conclusion: High-dose Yifei Qinghua granule has inhibitory effect on the proliferation of HUVEC and has a synergistic effect with gefitinib at 30 or 60μmol / L.