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目的观察米索前列醇用于预防产后出血的临床效果。方法选择668例阴道分娩者,随机分为三组:米索前列醇组280例,胎儿娩出后予后口服米索前列醇600μg;米索前列醇加缩宫素组198例,胎儿娩出后即予缩宫素10U肌注,同时口服米索前列醇600μg;缩宫素组190例,胎头娩出后予缩宫素10U肌注。观察各组产后2h内出血量。结果产后2h平均出血量:米索前列醇组为(175±45.1)ml;米索前列醇加缩宫组为(169±54.3)ml;缩宫素组为(258±78.4)ml。米索前列醇组与缩宫素组比较,差异有极显著性(P<0.001)。米索前列醇组与米索前列醇加缩宫素组,差异无显著性(P>0.05)。结论米索前列醇对子宫的收缩作用强于缩宫素,能较好地预防产后出血,用药既方便又安全。
Objective To observe the clinical effect of misoprostol in preventing postpartum hemorrhage. Methods 668 cases of vaginal delivery were randomly divided into three groups: 280 cases of misoprostol group, the fetus after oral administration of misoprostol 600μg; misoprostol plus oxytocin group of 198 cases, the fetus after delivery To oxytocin 10U intramuscular injection, at the same time oral misoprostol 600μg; oxytocin group 190 cases, fetal head after delivery of oxytocin 10U intramuscular injection. Observe the blood loss within 2 hours after delivery in each group. Results The average amount of bleeding after 2h postpartum was (175 ± 45.1) ml in misoprostol group, (169 ± 54.3) ml in misoprostol group and (258 ± 78.4) ml in oxytocin group. Misoprostol group and oxytocin group, the difference was significant (P <0.001). There was no significant difference between misoprostol group and misoprostol plus oxytocin group (P> 0.05). Conclusion Misoprostol is more effective than oxytocin in contracting uterus and can prevent postpartum hemorrhage well. It is convenient and safe to treat.