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目的:评价坦索罗辛治疗输尿管下段结石的临床效果。方法:将选取的120例输尿管下段结石患者随机分成两组,每组60例,结石直径0.4～1.0 cm。治疗组口服坦索罗辛0.4 mg,每晚1次,口服诺氟沙星胶囊0.2 g/次,每天3次,服药不超过2周,并适量饮水和运动;对照组仅口服诺氟沙星胶囊0.2 g/次,每天3次,适量饮水和运动。每例患者治疗观察期不超过2周。结果:2周内,治疗组排石率为83.3%(50/60),对照组为41.7%(25/60),两组比较排石率差异有统计学意义(P<0.01)。平均排石时间治疗组为5.1天,对照组为8.7天.两组比较差异有统计学意义(P<0.05)。因发生肾绞痛而需镇痛药治疗,治疗组有1例,对照组有9例。两组均未出现明显副作用,无因不能耐受而退出者。结论:坦索罗辛可明显提高结石排出率,减少排石时间,缓解肾绞痛症状,有促进输尿管下段结石排出的作用。
Objective: To evaluate the clinical effect of tamsulosin in the treatment of lower ureteral calculi. Methods: 120 patients with lower ureteral calculi were randomly divided into two groups, 60 cases in each group, with a diameter of 0.4 ~ 1.0 cm. The treatment group was given oral tamsulosin 0.4 mg once a night orally with norfloxacin 0.2 g once daily 3 times a day for less than 2 weeks and drinking water and exercising moderately. Capsule 0.2 g / time, 3 times a day, adequate water and exercise. Each patient treatment observation period of no more than 2 weeks. Results: In 2 weeks, the rate of stone discharging was 83.3% (50/60) in the treatment group and 41.7% (25/60) in the control group. There was significant difference between the two groups (P <0.01). The average time of stone row treatment group was 5.1 days and the control group was 8.7 days, the difference between the two groups was statistically significant (P <0.05). Nephropathy need to analgesic treatment, the treatment group, 1 case, control group, 9 cases. No obvious side effects were found in both groups and no patients were excluded due to unacceptable tolerance. Conclusion: Tamsulosin can significantly improve the rate of stone discharge, reduce the row of stone time, relieve the symptoms of renal colic, promote the lower ureteral stone discharge.