论文部分内容阅读
~(131)Ⅰ-碘化油作为肝癌的治疗剂,在肝癌病灶中的放射性强度高于正常组织3～8倍,并且贮留时间较长。一年后仍可在肝癌细胞中检测出。现介绍~(131)Ⅰ-碘化油的制备,并分析反应温度、pH值对其影响,选择最佳反应条件及贮存条件。方法:通常,在25ml圆底烧瓶内将Na~(131)Ⅰ与1ml乙醇混合,在搅拌和通N_2气条件下,将混合物在45℃和PEG400(聚乙二醇400)的油浴中加热至干。干品用1ml乙醇放2～5ml碘化油溶解,在80℃加热
131I-iodinated oil is a therapeutic agent for liver cancer, and its radioactivity intensity in liver cancer lesions is 3 to 8 times higher than that of normal tissues, and the retention time is longer. One year later, it can still be detected in liver cancer cells. The preparation of ~(131)I-iodinated oil is introduced, and the effects of reaction temperature and pH on the reaction are analyzed, and the best reaction conditions and storage conditions are selected. Method: In general, Na~(131)I is mixed with 1 ml of ethanol in a 25 ml round-bottom flask, and the mixture is heated in an oil bath of 45° C. and PEG 400 (polyethylene glycol 400) with stirring and N 2 gas. To dry. Dry product is dissolved with 2 ml to 5 ml of iodized oil in 1 ml of ethanol and heated at 80°C.