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在急性淋巴细胞白血病(急淋)中,发现了白血病细胞的特异性抗原,血清中存在抗体表明宿主能产生免疫反应。在急性粒细胞白血病(急粒)缓解期采取的血液淋巴细胞,与治疗前的自身白血病细胞一起培养时,能发生转化,而且淋巴细胞的反应性也因用经辐射的白血病细胞进行免疫而暂时地升高。在这两种白血病的完全缓解期内,残余的肿瘤细胞总数是小的。Mathe等首次报告急淋患儿应用免疫治疗是有效的,当由化疗诱导出现完全缓解时,应用经辐射的白血病细胞、卡介苗或两者合并使用的免疫治疗,结果免疫治疗组的中数缓解期远比对照组长。而英国医学研究委员会等报告,单独使用卡介苗不能延长急淋的缓解期。
In acute lymphoblastic leukemia (ALL), specific antigens of leukemia cells are found, and the presence of antibodies in the serum indicates that the host can produce an immune response. The blood lymphocytes taken during the remission of acute myeloid leukemia (acute granulocyte) are transformed when they are cultured together with pre-treatment leukemia cells, and the lymphocyte reactivity is temporarily due to immunization with irradiated leukemia cells. Increased. During the complete remission period of these two leukemias, the total number of residual tumor cells is small. Mathe et al. reported for the first time that immunotherapy was effective in patients with acute leukaemia. When complete remission was induced by chemotherapy, radiation therapy with leukemia cells, BCG or a combination of the two was used, resulting in an intermediate remission period in the immunotherapy group. Far longer than the control group. The British Medical Research Council reported that the use of BCG alone cannot prolong the remission period of acute showers.