目的探讨PTEN基因及血管内皮生长因子(VEGF)在脑星形细胞瘤中表达及其相关性。方法采用SP免疫组化法检测PTEN和VEGF在65例脑星形细胞瘤组织(A组)和10例正常脑组织(B组)中的表达。结果 A组PTEN表达阳性率为49.2%,明显低于B组的100%(P<0.01);A组VEGF表达阳性率为64.6%,B组无阳性表达。与低恶性度组比较,高恶性度组的PTEN低,而VEGF表达明显增高(P<0.05)。在脑星形细胞瘤组织中,PTEN与VEGF蛋白的表达呈负相关(r=-0.980,P<0.05)。结论 PTEN及VEGF均与脑星形细胞瘤发生及恶性程度密切相关;检测两者表达情况可为脑星形细胞瘤的临床诊治及预后判断提供依据。 Objective To investigate the expression of PTEN gene and vascular endothelial growth factor (VEGF) in brain astrocytoma and its correlation. Methods SP immunohistochemistry was used to detect the expression of PTEN and VEGF in 65 cases of astrocytoma (A group) and 10 cases of normal brain tissue (B group). Results The positive rate of PTEN expression in group A was 49.2%, which was significantly lower than that in group B (P <0.01). The positive expression rate of VEGF in group A was 64.6%. There was no positive expression in group B. Compared with the low-grade group, the PTEN of the high-grade group was low and the expression of VEGF was significantly increased (P <0.05). In brain astrocytoma, the expression of PTEN was negatively correlated with VEGF (r = -0.980, P <0.05). Conclusions Both PTEN and VEGF are closely related to the occurrence and malignant degree of astrocytoma. Detecting the expression of PTEN and VEGF may provide the basis for clinical diagnosis and prognosis of astrocytoma.