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将30只成年大鼠中的10只作为正常对照,自由饮用自来水,其余20只喂饲氨水4个月,制成慢性萎缩性胃炎模型,然后对其中的10只给予麦滋林—S治疗。分别检测正常对照组、胃炎模型组及麦滋林—S治疗组大鼠胃粘膜生长抑素(SS)、胃泌素(Gas)含量及胃液酸度、胃蛋白酶活性等指标。结果显示:与对照组相比,模型组SS含量、胃液酸度下降(P<005);Gas含量、胃蛋白酶活性及窦部pH均升高;治疗组同模型组相比,SS含量、胃液酸度升高:Gas含量下降至正常对照水平。这一结果说明,SS和Gas等指标可能反映胃炎的严重程度,通过对该组指标的检测可望判断治疗效果,具有一定的临床意义。
10 adult rats in 30 as a normal control, free to drink tap water, and the remaining 20 were fed ammonia for 4 months, made of chronic atrophic gastritis model, and then to 10 of them given Mai Zuolin-S treatment. Gastric mucosal somatostatin (SS), gastrin (Gas) and gastric juice acidity, pepsin activity and other indicators of the normal control group, gastritis model group and Mai Zuolin-S treatment group were detected. The results showed that compared with the control group, the content of SS and the acidity of gastric juice in model group decreased (P <005), the content of gas, pepsin activity and pH in sinusoid increased. Compared with model group, SS content, Gastric acidity increased: Gas content decreased to normal control levels. This result shows that SS and Gas and other indicators may reflect the severity of gastritis, by the detection of this group of indicators is expected to determine the treatment effect, with some clinical significance.