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目的 探讨载脂蛋白H(apoH)基因多态性与长沙地区汉族人脑卒中的关系。方法 采用PCR 单链构象多态技术和DNA序列测定法检测长沙地区汉族 2 6 0例脑卒中患者、2 0个脑卒中家系成员和 10 0例健康对照者的apoH基因 3号外显子的多态性。结果 长沙地区汉族人apoH基因 3号外显子存在G341A(Ser88Asn)多态 ,在脑出血 (CH)组 ,G341A (Ser88Asn)多态A等位基因频率(0 12 7)明显高于对照组 (0 0 5 5 ) (P <0 0 5 )。有高血压的CH组A等位基因频率 (0 15 1)明显高于对照组 (0 0 5 5 )及无高血压的CH组 (0 0 78) (P <0 0 5 ) ,而后两者比较无统计学意义 (P >0 0 5 )。有家族史的CH患者A等位基因频率 (0 15 0 )明显高于对照组 (0 0 5 5 ) (P <0 0 5 ) ,以CH为主的家系中患病组与未患病组A等位基因 (0 16 0 ,0 12 8)频率均明显高于对照组 (0 0 5 5 ) (P <0 0 5 )。apoH基因G341A(Ser88Asn)多态性与脑梗死无关。结论 G341A(Ser88Asn)多态A等位基因可能是长沙地区汉族人CH ,特别是高血压性CH及有家族史的CH患者的遗传危险因素。
Objective To investigate the relationship between apolipoprotein H (apoH) gene polymorphism and stroke in Han nationality in Changsha area. Methods Polymorphisms of exon 3 of apoH gene in 260 stroke patients, 20 stroke family members and 100 healthy controls in Han nationality in Changsha district were detected by PCR single strand conformation polymorphism and DNA sequencing. Sex. Results There was G341A (Ser88Asn) polymorphism in exon 3 of apoH gene in Han nationality in Changsha area. The allele frequency of G341A (Ser88Asn) polymorphism in CH group was significantly higher than that in control group (0 12 7) 0 5 5) (P <0 0 5). The frequency of allele A in CH group with hypertension (0 15 1) was significantly higher than that in control group (0 055) and CH group without hypertension (0 0 78) (P 0 05) There was no statistical significance (P> 0.05). Family A patients with CH allele A frequency (0 15 0) was significantly higher than the control group (0 055) (P <0 05), CH-based pedigree of the family and non-affected group The frequency of A allele (0 16 0, 0 12 8) was significantly higher than that of the control group (0 055) (P 0 05). ApoH gene G341A (Ser88Asn) polymorphism has nothing to do with cerebral infarction. Conclusion The G341A (Ser88Asn) Polymorphic A allele may be the genetic risk factor for Han CH, especially hypertensive CH and family history CH in Changsha district.