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采用中药小叶女贞中提取的有效成份Ｍ２静脉注射治疗慢性阻塞性肺疾患（ＣＯＰＤ）患者６７例，观察其止咳及平喘的作用，并测定其中３１名患者Ｍ２治疗前及治疗３０ｍｉｎ后的肺功能改变。结果发现静注Ｍ２后１０～２０ｍｉｎ内即出现快速的止咳和平喘作用，总有效率达９７％，其作用可维持４～１０ｈ；肺功能检测显示Ｍ２静注３０ｍｉｎ后患者肺活量（ＶＣ％）、用力呼气中段前速（ＦＥＦ２５％～７５％）显著改善。临床观察结果提示Ｍ２具有显著的止咳、平喘作用，肺功能指标则提示Ｍ２具有快速降低小气道阻力的作用。
Sixty-six patients with chronic obstructive pulmonary disease (COPD) were treated with M2, an effective ingredient extracted from Chinese medicinal lobular privet Ligustrum citrifolia, to observe its antitussive and antiasthmatic effects, and 31 patients with M2 before and 30min after treatment were measured. Functional changes. The results showed that a rapid cough and asthma action occurred within 10 to 20 minutes after intravenous injection of M2. The total effective rate was 97%, and the effect was maintained for 4 to 10 hours. Lung function tests showed that the patient’s vital capacity (VC%) was 30 minutes after M2 intravenous injection. Forced exhalation mid-segment speed (FEF 25% to 75%) significantly improved. Clinical observations suggest that M2 has significant antitussive and antiasthmatic effects, and lung function indicators suggest that M2 has the effect of rapidly reducing small airway resistance.