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目的探讨血脂水平与帕金森发病风险的关系及其对病情程度的预测价值。方法选择复旦大学附属中山医院2010-2014年收治的帕金森患者124例作为研究对象,选择同期124例健康体检者作为对照组,抽取研究对象空腹静脉血,检测血脂水平,包括总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)和载脂蛋白A1(Apo A1)水平,并计算Apo A1/HDL值,比较两组血脂水平及不同性别、年龄和H-Y分级帕金森患者血脂水平。用SPSS 19.0统计软件进行独立样本t检验和方差分析;用Spearman相关分析血脂水平与H-Y分级的关系。结果帕金森组TG水平与对照组比较,差异无统计学意义(P>0.05),帕金森组TC、LDL、HDL、Apo A1和Apo A1/HDL均明显低于对照组,差异均有统计学意义(P<0.05)。男女患者TG水平差异无统计学意义(P>0.05),男性患者TC、LDL、HDL、Apo A1和Apo A1/HDL均明显低于女性,差异均有统计学意义(P<0.05)。不同年龄患者间各项血脂指标比较,差异均无统计学意义(P>0.05)。不同H-Y分级的患者TC、TG、LDL、HDL、Apo A1差异均无统计学意义(P>0.05),但Apo A1/HDL组间差异有统计学意义(P<0.05),H-Y分级越高,Apo A1/HDL越低。相关性分析显示,Apo A1/HDL与帕金森H-Y分级呈明显的负相关(r=-0.179,P<0.05)。结论帕金森患者存在明显的低血脂情况,男性患者尤其明显,可见低血脂可能是帕金森发病的风险因素;另外,Apo A1/HDL与病情程度相关,或可作为预测帕金森严重程度的辅助指标。
Objective To investigate the relationship between the level of serum lipids and the risk of Parkinson’s disease and its predictive value of disease severity. Methods One hundred and forty-four patients with Parkinson’s disease admitted from 2010 to 2014 in Zhongshan Hospital of Fudan University were enrolled in this study. 124 healthy subjects were selected as the control group. Fasting venous blood samples were collected from the study subjects, including serum total cholesterol (TC) , Triglyceride (TG), low density lipoprotein (LDL), high density lipoprotein (HDL) and apolipoprotein A1 (Apo A1) were calculated and Apo A1 / HDL were calculated. Blood lipid level and gender , Age, and grade of Parkinson’s disease in patients with HY. Independent samples t-test and analysis of variance were performed with SPSS 19.0 statistical software; Spearman correlation analysis was used to analyze the relationship between the level of lipid and H-Y classification. Results There was no significant difference in TG level between the Parkinson group and the control group (P> 0.05). The levels of TC, LDL, HDL, Apo A1 and Apo A1 / HDL in Parkinson’s group were significantly lower than those in the control group Significance (P <0.05). The levels of TC, LDL, HDL, Apo A1 and Apo A1 / HDL in male patients were significantly lower than those in female patients (P <0.05). There was no significant difference in TG levels between male and female patients (P> 0.05). There was no significant difference in the indexes of blood lipid among patients of different ages (P> 0.05). There was no significant difference in TC, TG, LDL, HDL and Apo A1 among different HY grades (P> 0.05), but there was a significant difference between Apo A1 / HDL group (P <0.05) Apo A1 / HDL the lower. Correlation analysis showed a significant negative correlation between Apo A1 / HDL and Parkinson’s H-Y classification (r = -0.179, P <0.05). Conclusions There are obvious hypolipidemia in Parkinson’s disease patients, especially in male patients. It can be seen that hypolipidemia may be the risk factor of Parkinson’s disease. In addition, Apo A1 / HDL is related to the severity of illness, or may be used as an auxiliary index to predict the severity of Parkinson’s disease .