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目的:探讨高渗葡萄糖溶液在持续性异位妊娠(PEP)治疗中的应用价值。方法:将2011年1月至2013年12月诊治的PEP患者75例分成观察组和对照组,观察组45例在B超监视妇科手术仪监视下经宫腔输卵管注入50%葡萄糖溶液,对照组30例予甲氨蝶呤(MTX)肌肉注射,比较对两组治疗成功率、不良反应率及β-hCG转阴时间。结果:观察组的治疗成功率明显高于对照组(95.6%vs 70.0%,P<0.05),不良反应发生率明显低于对照组(4.4%vs 26.7%,P<0.05),β-hCG转阴时间显著少于对照组(14.2±5.9 d vs 19.4±4.6d,P<0.01)。结论:与甲氨蝶呤相比较,高渗葡萄糖溶液对PEP治疗更有效安全。
Objective: To investigate the value of hypertonic glucose solution in the treatment of persistent ectopic pregnancy (PEP). Methods: Seventy-five patients with PEP who were diagnosed and treated from January 2011 to December 2013 were divided into observation group and control group. 45 cases in the observation group were injected with 50% glucose solution through the uterine tubal under the supervision of B-ultrasound gynecological operation instrument, 30 cases were given methotrexate (MTX) intramuscular injection, compared the success rate of treatment, adverse reaction rate and β-hCG turn over time. Results: The success rate of treatment in observation group was significantly higher than that in control group (95.6% vs 70.0%, P <0.05), and the incidence of adverse reactions was significantly lower than that in control group (4.4% vs 26.7%, P <0.05) The febrile time was significantly less than that of the control group (14.2 ± 5.9 days vs 19.4 ± 4.6 days, P <0.01). Conclusion: Compared with methotrexate, hypertonic glucose solution is more effective and safe for PEP treatment.