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肿瘤化疗的重要任务,应选择新的高效抗肿瘤药物,并能提高现有细胞抑制剂的选择作用。两性霉素B是一种与肿瘤细胞膜类固醇起反应及改变膜通透性的膜活性物质,故能提高抗肿瘤制剂的选择性和增强机体的免疫力,减少抗肿瘤制剂的并发症。若与利尿剂合用能保持正常的水盐代谢和肾功能。方法选用不同种系的大、小白鼠1000只,分别载有肉瘤、骨髓组织增生、类淋巴细胞性白血病、肺癌、黑色素瘤、浆细胞瘤、肝肿瘤、癌肉瘤和淋巴肉瘤等。除骨髓组织增生和类淋巴性白血病是在接种后24小时治疗外,其余均在载瘤后10～20天内治疗。药物剂量两性霉素B50单位/公斤,尾静脉注
The important task of cancer chemotherapy should be to select new and highly effective anti-tumor drugs and to increase the selection of existing cytostatic drugs. Amphotericin B is a membrane-active substance that reacts with tumor cell membrane steroids and changes membrane permeability, so it can increase the selectivity of anti-tumor agents and enhance the body’s immunity, reducing the complications of anti-tumor agents. If combined with diuretics can maintain normal water and salt metabolism and renal function. Methods A total of 1000 large and small mice of different phylogenies were used. They contained sarcoma, bone marrow hyperplasia, lymphoid leukemia, lung cancer, melanoma, plasma cell tumor, liver tumor, carcinosarcoma and lymphosarcoma. Except for myeloproliferative and lymphoid leukemia, which were treated 24 hours after inoculation, the rest were treated within 10 to 20 days after the tumor was inoculated. Drug dose amphotericin B 50 units/kg, tail vein note