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目的探讨中西医结合方案在治疗老年多发性骨髓瘤(MM)患者中的临床应用价值。方法 75例老年MM患者随机分成三组,每组25例,对照组釆用标准VAD方案治疗,观察1组釆用标准VAD方案+艾迪注射液治疗,观察2组釆用标准VAD方案+艾迪注射液+沙利度胺治疗。比较三组患者治疗结束时临床有效率、卡氏(KPS)评分情况、骨髓浆细胞比例及血清M蛋白水平。结果观察2组患者治疗后的有效率(88.0%)高于对照、观察1组(52.0%);观察2组患者治疗后体力状况改善率(84.0%)高于对照组(44.0%)(P<0.05)。观察2组患者治疗后骨髓浆细胞比例及血清M蛋白水平低于对照组、观察1组(P<0.05)。结论在VAD方案治疗MM的基础上联合应用艾迪注射液及沙利度胺可提高患者治疗的有效率,明显改善患者体力状况,并能有效降低患者治疗后骨髓浆细胞比例及血清M蛋白水平,是老年MM患者较为理想的一种治疗选择。
Objective To explore the clinical application of integrated traditional Chinese and western medicine in the treatment of elderly patients with multiple myeloma (MM). Methods 75 elderly MM patients were randomly divided into three groups, 25 cases in each group. The control group was treated with standard VAD regimen. One group was treated with standard VAD regimen and Aidi injection. The two groups were treated with standard VAD regimen + Ai Di injection + thalidomide treatment. Clinical efficacy, Karnaugh’s (KPS) score, proportion of bone marrow plasma cells and serum M protein levels were compared between the three groups at the end of treatment. Results After treatment, the effective rate (88.0%) in the two groups was significantly higher than that in the control group (52.0%). The improvement rate of physical status (84.0%) in the two groups after treatment was significantly higher than that in the control group (44.0%) <0.05). After treatment, the proportion of plasma cells and the level of serum M protein in the two groups were lower than those in the control group (P <0.05). Conclusion The combination of Aidi Injection and thalidomide on the basis of VAD regimen can improve the efficiency of treatment, significantly improve the physical condition of patients and reduce the proportion of plasma cells and serum M protein , Is an ideal elderly patients with MM treatment options.