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目的探讨肝癌间质和癌旁病变对肝癌诊断的临床意义。方法选择2010年1月至2015年1月间延安大学咸阳医院病理科收治的肝癌组织患者80例,癌结节共180个。癌旁组织以及肝癌间质各取4块结节组织作为标本,常规包埋切片,显微镜观察结节情况。结果被完整内皮细胞围绕结节76个,其中<3 cm 52个,≥3 cm 24个。剩余104个结节均未被完整内皮细胞围绕,<3 cm 96个,≥3 cm仅8个。80例肝癌患者中,52例合并有肝硬化,68例合并有乙型肝炎病毒感染(HBV)且乙肝表面抗原(HBs Ag)阳性。结论病理进行连续切片并在显微镜下对肝癌间质及癌旁病变情况进行观察是目前临床预测肝癌患者预后的一个重要病理学指标。
Objective To investigate the clinical significance of liver cancer interstitial and adjacent non-cancerous lesions in the diagnosis of liver cancer. Methods From January 2010 to January 2015, 80 cases of HCC tissues and 180 cancerous nodules were collected from the Department of Pathology, Xianyang Hospital, Yan’an University. Paracancerous tissue and liver cancer stroma each take 4 nodules as specimens, routine embedded sections, microscopic observation of nodules. The results were complete endothelial cells around the nodules 76, of which <3 cm 52, ≥ 3 cm 24. The remaining 104 nodules were not surrounded by intact endothelial cells, 96 cm in size <3 cm and only 8 in ≥ 3 cm. Of the 80 patients with hepatocellular carcinoma, 52 had cirrhosis and 68 had hepatitis B virus (HBV) positive and hepatitis B surface antigen (HBsAg) was positive. Conclusions It is an important pathological index to predict the prognosis of patients with hepatocellular carcinoma by serial sectioning and microscopically observing the interstitial and para-cancerous lesions of liver cancer.