论文部分内容阅读
半合成利福霉素RF-101是我们在1974年试制成功的五种利福霉素衍生物之一。国外文献报道,利福霉素衍生物对于RNA病毒的逆转录酶有抑制作用,某些利福霉素衍生物对DNA病毒和病毒感染的细胞病灶有抑制作用。又有报道,某些利福霉素衍生物对化学致癌物质诱发的小鼠肿瘤有一定的抑制作用。根据肿瘤的病毒学说,我们设想由于利福霉素衍生物对RNA的DNA聚合酶(逆转录酶)有强烈的抑制作用,而可能对肿瘤呈抑制作用。因此,选择性地试制了五种利福霉素衍生物,即RF-100(AF/DNF1),RF-101(AF/ABP),RF-102(AF/AP),RF-103(AF/013),RF-104(AF/ABDP),其化学结构如下:
The semi-synthetic rifamycin RF-101 is one of the five rifamycin derivatives we successfully tested in 1974. Foreign literature, rifamycin derivatives for RNA virus reverse transcriptase inhibition, some rifamycin derivatives on DNA virus and virus infection of the cell lesions have an inhibitory effect. It has also been reported that some of the rifamycin derivatives have certain inhibitory effect on tumor induced by chemical carcinogens. Based on the viral theory of the tumor, we hypothesized that the rifamycin derivative may have a suppressive effect on the tumor because of its strong inhibitory effect on RNA polymerase (reverse transcriptase). Thus, five derivatives of rifamycin were selectively prepared, namely RF-100 (AF / DNF1), RF- 101 (AF / ABP), RF- 102 (AF / AP) 013), RF-104 (AF / ABDP), the chemical structure is as follows: