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目的 测定腹腔注射盐酸川芎嗪后不同时间兔眼视网膜川芎嗪的浓度 ,计算其药动学参数 ,研究其药动学特点。方法 4 4只家兔随机分为 11组 ,每只家兔腹腔注射盐酸川芎嗪 80mg·kg-1,在用药前 (0h)和用药后 0 2 5、0 5、0 75、1、1 5、2、3、5、8、12h取视网膜 ,采用反向高效液相色谱法 (RP HPLC)进行测定。 3P87软件拟合药动学参数。结果 腹腔注射盐酸川芎嗪后 ,其浓度在正常家兔眼视网膜呈开放型二室模型。理论值高峰浓度 (Cmax)为 1 6 3mg·g-1,达收稿日期 :2 0 0 4-0 1-3 1,修回日期 :2 0 0 4-0 2 -2 8基金资助 :广东省自然科学基金 (张清炯 0 10 765 )、国家自然科学基金(杨锦南 3 0 3 0 0 467)和广东省中医药管理局科学基金 (邓新国 10 40 0 64 )资助项目作者简介 :邓新国 ( 1961-) ,男 ,博士 ,研究方向 :眼科药物的开发、药理、药效和药代动力学研究 ;胡世兴 ( 195 2 -) ,男 ,博士 ,美国波士顿哈佛医学院眼科及免疫学博士后研究员 ,教授 ,博士生导师 ,通讯作者 ,Tel:0 2 0 873 3 0 2 89,E mail:Markhu @2 63 .net峰时间 (Tmax)为 0 32h ,半衰期T1/ 2α为 0 35h ,T1/ 2 β为 2 5 0h ,清除率 (CL)为 7 89g·h-1。实测值 15min为 (1 36± 0 16 )mg·g-1,30min达高峰为 (2 5 9± 0 19)mg·
Objective To determine the concentration of tetramethylpyrazine in retina of rabbits after intraperitoneal injection of tetramethylpyrazine hydrochloride and calculate its pharmacokinetic parameters and study its pharmacokinetic characteristics. Methods 4 4 rabbits were randomly divided into 11 groups, each rabbit intraperitoneal injection of ligustrazine hydrochloride 80mg · kg-1, before treatment (0h) and after treatment 0255,05,0 75,1,1 5 , 2, 3, 5, 8, 12 h retina was taken and determined by reverse-phase high-performance liquid chromatography (RP HPLC). 3P87 software fitting pharmacokinetic parameters. Results Intraperitoneal injection of Ligustrazine Hydrochloride, its concentration in the normal rabbit retina was open two-compartment model. The theoretical peak concentration (Cmax) of 1 6 3 mg · g-1, up to date: 200 0 4-0 1-3 1, the repaired date: 2 0 0 4-0 2 -2 8 Fund: Guangdong (1961-), National Natural Science Foundation of China (Yang Jinnan 3 0 3 0 0 467) and Guangdong Provincial Traditional Chinese Medicine Science Foundation (Deng Xin-guo 10 40 064). Ph.D., Ph.D., Ph.D., Ph.D. Research Interests: Development, Pharmacology, Pharmacodynamics and Pharmacokinetics of Ophthalmic Drugs; Hu Shih-hsien, Ph.D., PhD, Postdoctoral Fellow, Ophthalmology and Immunology, Harvard Medical School, Boston, Lifetime Instructor, Corresponding Author, Tel: 0 2 0 873 3 0 2 89, E-mail: Markhu @ 2 63. Net peak time (Tmax) is 0 32 h, half life T1 / 2α is 0 35 h, T1 / 2 β is 2 5 0h, clearance rate (CL) of 7 89g · h-1. The peak value at 15 min was (366 ± 0 16) mg · g-1 at 30 min and reached (259 ± 0 19) mg ·