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目的探讨国产曲美他嗪在治疗不稳定型心绞痛中的价值。方法选取不稳定型心绞痛患者160例,将其随机分为两组,对照组80例应用常规药物,另80例为国产曲美他嗪组,在对照组治疗基础上加用国产曲美他嗪。治疗后2个月,主要通过门诊复查和电话随访获得患者相关信息,包括两组患者的心电图缺血表现、心绞痛发作、再次入院治疗、急性心肌梗死、脑血管意外(急性脑梗死或脑出血)、死亡例数及严重出血、胃肠道不适症状、皮下紫斑、头部不适症状。结果治疗后2个月,国产曲美他嗪组心绞痛发作7例(8.8%),再次入院3例(3.8%),心电图缺血6例(7.5%),均低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较差异未见统计学意义(P>0.05)。结论在常规治疗药物的基础上加用国产曲美他嗪能有效控制和预防心绞痛发作,降低再次入院率,但未增加不良反应。
Objective To investigate the value of domestic trimetazidine in the treatment of unstable angina pectoris. Methods 160 patients with unstable angina pectoris were selected and randomly divided into two groups. 80 cases in the control group were treated with conventional drugs and the other 80 cases were domestic trimetazidine group. On the basis of the control group, the domestic trimetazidine . Two months after treatment, patient-related information was obtained mainly through outpatient visits and telephone follow-ups, including ECG-based electrocardiographic findings, angina pectoris, rehospitalization, acute myocardial infarction, cerebrovascular accident (acute cerebral infarction or intracerebral hemorrhage) , The number of deaths and severe bleeding, gastrointestinal symptoms, subcutaneous purple spots, headache symptoms. Results In the 2 months after treatment, angina pectoris occurred in 7 cases (8.8%) in domestic trimetazidine group, 3 cases (3.8%) in remission and 6 cases (7.5%) in electrocardiogram ischemia, which were all lower than those in control group Significance (P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusion The addition of domestic trimetazidine to conventional therapies can effectively control and prevent the onset of angina pectoris and reduce the rate of re-admission but does not increase adverse reactions.