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目的 比较吗丙嗪 (Pro) ,乙双吗啉 (Bim)和丙亚胺(Raz)对动物肿瘤肺转移的影响。方法 用生物接种法进行Lewis癌肺转移的观测。结果 Pro和Bimd 2起给药和d 8起给药对Lewis癌肺转移均有抑制 ,Raz仅d 2起给药对Lewis癌肺转移有影响 ,Pro在等毒性剂量下对Lewis癌肺转移疗效优于Bim。结论 Pro的抗Lewis癌肺转移疗效优于Raz可能是由于其存在新的分子药理机制。
Objective To compare the effects of promazine, Bim and Raz on pulmonary metastasis in animal tumors. Methods The biological inoculation method was used to observe the lung metastasis of Lewis lung carcinoma. Results Pro and Bimd 2 administration and d 8 administration inhibited the lung metastasis of Lewis lung cancer. Raz only d 2 administered had an effect on the lung metastasis of Lewis lung cancer. Pro was equally effective in Lewis lung metastasis Better than Bim. Conclusion Pro-anti-Lewis lung cancer metastasis is superior to Raz in that it may be due to its new molecular pharmacological mechanism.