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目的了解清开灵注射液引发药源性疾病的种类,分析清开灵注射液导致不良反应(ADR)/药源性疾病的原因及影响因素。方法通过检索2003-2008年中国医院知识全库(CNKD)期刊全文,收集个案病例166例,并将资料分类统计进行分析。结果本资料共收集166例个案,其中男性74人,女性92人,有61人有药物或食物过敏史,发生ADR的时间,最短2min,一般5～30min,所引发的药源性疾病主要为药源性皮肤病、药源性过敏反应、过敏性休克、药源性血液系统疾病、药源性心脏病、药源性精神疾病等。结论清开灵注射液所可引发的多种药源性疾病,临床应合理应用并加强监测。
Objective To understand the types of drug-induced diseases caused by Qingkailing injection and analyze the causes and influencing factors of Qingkailing injection-induced adverse drug reactions (ADR) / drug-induced diseases. Methods Through the retrieval of the full text of CNKD Journal from 2003 to 2008, 166 cases were collected and classified according to statistics. Results A total of 166 cases were collected in this study, including 74 males and 92 females, 61 had drug or food allergy history, the time of occurrence of ADR, the shortest 2min, usually 5 ~ 30min, the drug-induced diseases are mainly Drug-induced dermatosis, drug-induced allergic reactions, anaphylactic shock, drug-induced hematological diseases, drug-induced heart disease, drug-induced mental illness. Conclusions Qingkailing injection can lead to a variety of drug-induced diseases, the clinical application should be reasonable and strengthen monitoring.