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采用免疫组化 (S P法 )检测了 40例胃癌组织中CD44的表达情况。结果发现胃癌组织中CD44阳性表达率为 70 % (2 8/ 40 ) ,侵及浆膜层及浆膜外阳性率为 76 5 % (2 6 / 34) ,明显高于未侵及浆膜层者 33 3% (P <0 0 5 ) ,伴淋巴结转移的阳性率为 78 6 % (2 2 / 2 8) ,显著高于无淋巴结转移者 33 3 % (P <0 0 1)。结论提示CD44表达与胃癌的浸润深度和淋巴结转移密切相关 ,对评估胃癌浸润程度和淋巴结转移有一定价值。
The expression of CD44 in 40 cases of gastric carcinoma was detected by immunohistochemistry (S P method). The positive rate of CD44 expression in gastric cancer tissues was 70% (2/40). The positive rate of invading the serosa and serosa was 76.5% (26/34), which was significantly higher than that of non-invasion and serosa The positive rate of lymph node metastasis was 33.3% (P <0.05), 78.6% (22/28) in patients with lymph node metastasis, which was significantly higher than 33.3% (P <0.01) without lymph node metastasis. Conclusion The results suggest that CD44 expression is closely related to the depth of invasion and lymph node metastasis of gastric carcinoma, which is of value in assessing the degree of gastric cancer invasion and lymph node metastasis.