目的　探讨环孢素A(CsA)移植肾毒性损害的病理特点 ,以指导临床用药。　方法　对3 2例移植肾进行病理取材 ,HE染色 ,光镜下观察移植肾组织病理变化。　结果　 2 5例有CsA肾毒性损害者中急性 2 3例 ,主要病理变化为肾小管上皮空泡样变性 ;慢性 2例 ,病理变化为血管及间质的玻璃样和粘液样变。　结论　CsA对移植肾毒性损害的主要病理特点是肾小管上皮的空泡样变性和血管的玻璃样变 Objective To investigate the pathological features of cyclosporin A (CsA) -transplanted nephrotoxicity to guide clinical application. Methods 32 cases of renal allografts were harvested and stained with hematoxylin and eosin (HE). The pathological changes of renal allografts were observed under light microscope. Results Twenty-five acute cases with renal damage caused by CsA nephrotoxicity were found in 23 cases. The main pathological changes were tubular vacuolar degeneration in renal tubular epithelial cells. Chronic 2 cases showed pathological changes of vitreous and myxoid changes of vessels and interstitium. Conclusion The main pathological features of CsA-induced nephrotoxicity are vacuolar degeneration of renal tubular epithelial cells and vitreous changes of blood vessels