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大鼠用3％凝固汽油(0.6ml/10cm~2)于脱毛的背部造成20％BSA的Ⅲ°烧伤以后,补给正常生长需要量的维生素E(VE)0.2mg·100gbw~(-1).d~(-1),满足不了体内的需要。血清和肝脏VE的含量低于补给同样剂量的正常对照组,但血浆LPO却高于正常对照组。伤后14天,组织形态学检查可见到胸腺萎缩,皮质变薄,细胞皱缩,脾脏生发中心减少,睾丸萎缩,精子和精母细胞减少。当伤后补给VE的剂量增加到2mg·100gbw~(-1)·d~(-1)时,不仅血清和肝脏VE含量明显升高,而且血浆LPO含量也降到正常对照组水平;同时胸腺、脾脏和睾丸的组织形态学也接近正常对照组。
Rats were anesthetized with 3% coagulated petrol (0.6 ml / 10 cm ~ 2) and burned to 20% BSA for 3 ° burns on the back of their hair. The rats were then given supplemental vitamin E (VE) 0.2 mg · 100 gbw -1. d ~ (-1), can not meet the needs of the body. Serum and liver VE levels were lower than the same dose of normal control group, but the plasma LPO was higher than the normal control group. Fourteen days after injury, atrophy of the thymus, thinning of the cortex, shrinkage of the cells, reduction of the germinal center of the spleen, atrophy of the testis and reduction of sperm and spermatocytes were observed by histomorphologic examination. When the dose of VE was increased to 2mg · 100gbw -1 d -1, not only the serum and liver VE levels were significantly increased, but also the plasma LPO levels were also reduced to normal control group; at the same time, the thymus The morphology of spleen and testis were also close to the normal control group.