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初期细胞的化学敏感性和急性淋巴细胞白血病CALL)的最后临床预后之间的关系,尚未见过报道。对3-(4.5二甲基噻唑-2基)[-2,5二苯基四唑溴化物(MTT)的测定,使这项研究成为可能性。本文报道了在患ALL 的儿童最初诊断时所应用的5种白血病化疗药物之试管内敏感性和长期临床预后之间的关系。采用患前驱性B-ALL 或T-ALL 的82例儿童最初诊断时的骨髓或外周血细胞进行研究。所有病人接受强的松龙、长春新碱、Colaspase(天门冬酰氨酶)、巯基嘌呤和氨甲喋呤,并且多数病人也接受蒽环类抗生素治疗。完全缓解下定义为:骨髓白血病细
The relationship between chemosensitivity of primary cells and the final clinical outcome of acute lymphoblastic leukemia CALL has not been reported. The determination of 3-(4.5-dimethylthiazol-2-yl)[-2,5-diphenyltetrazolium bromide (MTT) makes this study possible. This article reports the relationship between in vitro sensitivity and long-term clinical outcome of five leukemia chemotherapeutic agents used in the initial diagnosis of children with ALL. Bone marrow or peripheral blood cells were initially studied in 82 children with preexisting B-ALL or T-ALL. All patients received prednisolone, vincristine, colaspase (asparaginase), mercaptopurine, and methotrexate, and most patients also received anthracycline antibiotics. Complete remission is defined as: bone marrow leukemia fine