论文部分内容阅读
为了寻找扩张脑血管的新药,本文用D(-)-(?)-氨基丁醇将(±)-(?)羟基苯乙酸(扁桃酸)拆分成左、右旋对映体,再分别与顺式3.3.5-三甲基环已醇酯化,制得二个有旋光性的环扁批酸酯(Ⅵ,Ⅶ);此外,还合成了与它们相应的菸酸酯盐酸盐(Ⅷ,Ⅸ)及安妥明酸酯(Ⅹ,Ⅺ)。 (±)环扁桃酸酯的安妥明酸酯(Ⅲ)、丙酸酯(Ⅳ)及2-甲基丙酸酯(Ⅴ)、3.3.5-三甲基环已醇的顺反异构体的3.4-二甲氧基苯甲酸酯(ⅩⅢ、ⅪⅤ)和3.4.5-三甲氧基苯甲酸酯(ⅩⅤ.ⅩⅥ)也分别被合成。
In order to search for a new drug for dilating cerebrovascular, (±) - (?) - hydroxyphenylacetic acid (mandelic acid) was resolved into left and right handed enantiomers by D (-) - Esterification with the cis-3,3,5-trimethylcyclohexanol gave two optically active cyclopropanamides (VI, VII); in addition, nicotinate esters corresponding to them were also synthesized (Ⅷ, Ⅸ) and sodium thiosumate (Ⅹ, Ⅺ). (III), propionate (IV) and 2-methylpropionate (V) of the (±) cyclodesomanate, cis and trans isomers of 3.3.5-trimethylcyclohexanol Of 3,4-dimethoxybenzoates (XIII, XIV) and 3.4.5-trimethoxybenzoate (XV.XVI) were also synthesized separately.