This paper will briefly discuss the issue of how different participant relatiom affect adjacency pairs in conversation analysis. In terms of the affects or influence on adjacency pairs, this article only places its focus on the ways how the first pair part (FPP) and second pair part (SPP) in conversation are relevant to each other. As for the final result, the data back up such conclusions: in conversation between ac-quaintance/friends, family members, and as such, the relevance are built up either directly or indirectly. However, in conversation between strangers, this relevance seems to be constructed only directly.