采用原子吸收光谱法测定脏器组织中铂浓度的方法，在大鼠体内研究白蛋白对卡铂腹腔内化疗体内分布的影响。实验结果表明：卡铂和白蛋白联用后，各脏器组织中铂浓度均增高，给药后７ｄ内肝、胃、肠、肺、腹膜和盆腔组织中浓度有差异，而肾组织中铂浓度仅在给药后１ｄ有差异。这提示白蛋白可增强卡铂腹腔内化疗效果，对肾脏影响较小。 Atomic absorption spectrometry was used to measure the platinum concentration in the organ tissue. The effect of albumin on the distribution of carboplatin intraperitoneal chemotherapy in rats was studied in vivo. The experimental results showed that after the combination of carboplatin and albumin, the platinum concentration in all organs increased, and there were differences in liver, stomach, intestine, lung, peritoneum, and pelvic tissues within 7 days after administration, while platinum in renal tissues. The concentration differed only 1 d after administration. This suggests that albumin can enhance the effect of carboplatin intraperitoneal chemotherapy and has less effect on the kidneys.