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目的:探讨高原地区不同民族慢性萎缩性胃炎(CAG)与血清胃蛋白酶原(PG)的关系,以及Hp感染对其的影响。方法:利用日立7170S型全自动生化分析仪,采用速率法测定经内镜检查和病理学确诊的慢性萎缩性胃炎376例(汉族143例,回族110例,藏族123例)患者的血清PG水平,并与39例胃黏膜基本正常(NOR)者作对比分析,同时观察Hp感染对不同民族CAG血清PG水平的影响。结果:不同民族CAG患者和正常者Hp检出率均高,平均达80.79%,各民族之间无统计学差别(P>0.05);Hp感染对不同民族CAG患者和正常者血清PG水平和PGⅠ/PGⅡ值均无显著影响(均P>0.05);汉族、回族和藏族CAG患者血清PGⅠ水平和PGⅠ/PGⅡ值明显低于正常者(P<0.01),而回族CAG患者血清PGⅠ水平和PGⅠ/PGⅡ值又明显低于汉族和藏族(P<0.05),汉族和藏族之间无统计学差别(均P>0.05);血清PGⅡ水平仅回族明显低于正常者(P<0.01),而汉族、回族和藏族之间均无统计学差别(均P>0.05);不同民族CAG患者男女之间血清PGⅠ、PGⅡ水平和PGⅠ/PGⅡ值均无显著性差别(均P>0.05)。结论:Hp感染对高原地区不同民族CAG患者血清PG水平无影响。不同民族CAG患者中血清PG水平存在差别,表现为回族明显低于汉族和藏族,而同民族不同性别之间无差别。
Objective: To investigate the relationship between chronic atrophic gastritis (CAG) and serum pepsinogen (PG) in different ethnic groups in the plateau and the influence of Hp infection. Methods: Using the Hitachi 7170S automatic biochemical analyzer, serum PG levels in 376 patients with chronic atrophic gastritis diagnosed by endoscopy and pathology (143 in Han, 110 in Hui and 123 in Tibet) And compared with 39 cases of normal gastric mucosa (NOR), and observed the effect of Hp infection on serum PG levels in CAG of different ethnic groups. Results: The prevalence of Hp in CAG patients and normal subjects from different ethnic groups was high, with an average of 80.79%. There was no significant difference among all ethnic groups (P> 0.05). The serum levels of PGs and PGⅠ PGⅠ and PGⅠ / PGⅡ in Han, Hui and Tibetan CAG patients were significantly lower than those in normal controls (P <0.01), while serum PGⅠ and PGⅠ / PGⅡ was significantly lower than that of Han and Tibetan (P <0.05), but there was no significant difference between Han and Tibetan (P> 0.05) There was no significant difference between Hui and Tibetans (all P> 0.05). There was no significant difference in serum PGⅠ, PGⅡ and PGⅠ / PGⅡ between men and women in different ethnic CAG patients (all P> 0.05). Conclusion: Hp infection has no effect on serum PG levels in CAG patients of different nationalities in plateau area. There is a difference in serum PG levels among CAG patients of different nationalities, showing that the Hui nationality is significantly lower than Han nationality and Tibetan nationality, but there is no difference between different ethnic groups.