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目的 为进一步探讨骨疏康防治骨质疏松的作用机理。方法 将 2 7只 3月龄Wistar雌性大鼠随机分为三组 :假手术组 (Sham)、卵巢切除组 (OVX)、骨疏康组 (GSK)。给药后 12周同时处死。取大鼠血、尿检测骨代谢生化指标 ,取股骨或腰椎测量骨密度、骨形态计量学参数、骨生物力学参数 ,取股骨和胫骨 ,测定骨粘连蛋白 (ON)mRNA表达。结果 与OVX组相比 ,GSK组股骨及L4 骨密度明显增高 ,生物力学参数也有增加。GSK有抑制骨吸收作用。结论 GSK增加骨量和骨强度的作用
Objective To further explore the mechanism of Gushukang in preventing and treating osteoporosis. Methods Twenty-seven 3-month-old Wistar female rats were randomly divided into three groups: Sham, Ovariectomy (OVX), and Gushikang (GSK). Simultaneous sacrifice was performed 12 weeks after administration. Take rats blood and urine to detect bone metabolism biochemical indicators, take the femur or lumbar vertebrae to measure bone density, bone morphometry parameters, bone biomechanical parameters, take the femur and tibia, measure osteonectin (ON) mRNA expression. Results Compared with the OVX group, the bone density of the femur and L4 in the GSK group was significantly higher and the biomechanical parameters were also increased. GSK inhibits bone resorption. Conclusion GSK increases bone mass and bone strength