以带黑色素瘤(B16)C57BL/6小鼠为模型,用光镜、电镜、形态计量学、淋巴细胞细胞毒等实验技术,对小鼠局部淋巴结的生物学屏障进行了研究。接种瘤细胞后,早期所出现的副皮质区增生和窦阳性反应,对机体抗肿瘤作用有利;晚期淋巴小结的增多和窦退化型反应的出现,则为机体抗肿瘤能力减弱的表现。 Using B16 C57BL/6 mice as a model, the biological barriers of regional lymph nodes in mice were studied by light microscopy, electron microscopy, morphometrics, and lymphocyte cytotoxicity. Inoculation of tumor cells, the early occurrence of paracortical hyperplasia and sinus-positive reactions, the body’s anti-tumor effect is favorable; late lymphoid nodules increased and the emergence of sinus degeneration response, the body’s anti-tumor ability to weaken the performance.