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目的探讨Livin和Caspase-3在胃癌组织细胞中的表达及临床意义。方法用免疫组化法检测75例胃癌组织和36例癌旁正常组织细胞中Livin、Caspase-3蛋白的表达情况。结果①Livin蛋白在胃癌组织中的表达率（76.7﹪）高于癌旁正常组织（14.3﹪）；Caspase-3蛋白在胃癌组织中的表达率（17.3﹪）低于癌旁正常组织（74.3﹪），均具有统计学意义（<0.05）；②Livin和Caspase-3表达呈负相关(<0.01)；③Livin阳性表达率与组织分化程度、淋巴结转移相关（<0.05）；Caspase-3的阳性表达率与组织细胞的分化程度及淋巴结转移相关（<0.05）。结论 Livin蛋白低表达和Caspase-3蛋白高表达参与了胃癌的发生、分化和淋巴结转移。“,”Objective To evaluate expression of Livin and Caspase-3 in human gastric carcinoma. Methods Immunohistochemical staining was applied to detect the expression of Livin and Caspase-3 in 75 cases of gastric carcinoma tissues and 36 cases of adjacent normal gastric mucosa. Results ①Livin protein positive expression rates (78.7﹪) in the gastric carcinoma tissues were higher than the adjacent normal gastricmucosa (14.3﹪)( <0.05). Caspase-3 protein positive expression rates(17.3﹪) in the gastric carcinoma tissues were lower than the adjacent normal gastric mucosa (74.3﹪)( <0.05).②The expression of caspases-3 was negatively with the exprssion of Livin( <0.01).③The expression of Livin was closely cor elated with?tissue dif erentiation, lymph node metastasis ( <0.05);The expression of Caspase-3 was closely cor elated with?tissue dif erentiation, lymph node metastasis ( <0.05). Conclusion The abnormal expression of Livin and Caspase-3 protein may play a role in the ccur ence , dif erentiation and lymph node metastasis of gastric carcinoma.