人类免疫缺陷症病毒(HIV)感染的临床特征大多可归因于被感染个体的极度免疫缺陷。HIV的这种免疫抑制作用又可因其对某一特定淋巴细胞亚群的嗜性所引起。HIV主要作用于T淋巴细胞,称为辅助/诱导细胞。这些细胞表面带有一种称为CD4的糖蛋白分子,已证明它能与HIV包膜糖蛋白结合。带有CD4的淋巴细胞遭破坏可能就是HIV产生免疫抑制作用的原因。最近已认识到在其他细胞上也有CD4分 Much of the clinical features of human immunodeficiency virus (HIV) infection can be attributed to the extreme immunodeficiency of infected individuals. This immunosuppressive effect of HIV can in turn be caused by its tropism for a particular subset of lymphocytes. HIV mainly acts on T lymphocytes, called helper / induced cells. The surface of these cells carries a glycoprotein called CD4 that has been shown to bind to the HIV envelope glycoprotein. The destruction of lymphocytes with CD4 may be responsible for the immunosuppressive effects of HIV. It has recently been recognized that there are CD4 scores on other cells as well