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目的:探讨胸苷磷酸化酶(TP)、中期因子(MK)和CD105在喉鳞状细胞癌组织中的表达及临床意义。方法:采用免疫组织化学方法检测43例喉鳞状细胞癌组织中TP、MK的表达和CD105标记的微血管密度(MVD)情况。结果:TP的阳性表达率为67.4%,MK的阳性表达率为60.5%,CD105标记的MVD值为6.01±1.78。TP和MK均为阳性时CD105标记的MVD值(7.07±3.26)明显高于TP和MK均为阴性时的MVD值(4.03±1.90)(P<0.05)。三者表达均与临床分期、淋巴结转移有关。单因素分析显示TP、MK表达和高MVD(≥6)均影响喉癌患者的生存期,但通过多因素分析显示只有淋巴结转移和MVD是影响喉癌患者生存期的预后因素。结论:TP、MK表达与喉癌血管生成关系密切,是喉癌肿瘤血管生成的重要因子,三者与喉癌进展、淋巴结转移密切相关。淋巴结转移和CD105标记的MVD是影响喉癌预后的因素;TP、MK可能通过促肿瘤血管生成作用对喉癌预后产生影响;TP、MK及CD105可作为一组有价值的肿瘤标记和预后指标。
Objective: To investigate the expression and clinical significance of thymidine phosphorylase (TP), midkine (MK) and CD105 in laryngeal squamous cell carcinoma. Methods: The expressions of TP, MK and MVD in 43 laryngeal squamous cell carcinomas were detected by immunohistochemistry. Results: The positive rate of TP was 67.4%, the positive rate of MK was 60.5%, and the positive rate of CD105 was 6.01 ± 1.78. The MVD value of CD105 labeling (7.07 ± 3.26) was significantly higher for both TP and MK than for both TP and MK (4.03 ± 1.90) (P <0.05). The three expressions were related to clinical stage and lymph node metastasis. Univariate analysis showed that TP, MK expression and high MVD (≥6) all affected the survival of patients with laryngeal cancer, but multivariate analysis showed that only lymph node metastasis and MVD were the prognostic factors affecting the survival of patients with laryngeal cancer. Conclusion: The expressions of TP and MK are closely related to the angiogenesis of laryngeal carcinoma, which are important factors of angiogenesis in laryngeal carcinoma. The three are closely related to the progression of laryngeal carcinoma and lymph node metastasis. Lymph node metastasis and CD105-labeled MVD are the prognostic factors of laryngeal carcinoma. TP and MK may have an effect on the prognosis of laryngeal carcinoma through promoting tumor angiogenesis. TP, MK and CD105 may serve as a valuable indicator of tumor marker and prognosis.