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Etoposide(4’脱甲基-表鬼臼毒素-β-D亚乙基糖苷)是从植物中提取的鬼臼毒素的半合成衍生物。作用机理与鬼臼毒素和通常的植物生物硷不同,其特点是不阻碍微小管的集合,依据用药剂量的不同,据说能可逆地切断单链DNA。此外,通过阻止摄入核苷,不可逆地终止细胞周期的S~G_2期而发挥抗肿瘤活性。临床二期试验通过口服和静脉用药,对肺癌、睾丸肿瘤、膀胱癌、前列腺癌、肾癌、恶性淋巴瘤、急性白血病(AML)进行试验。用
Etoposide (4'demethyl-epipodophyllotoxin-[beta]-D ethyleneglycoside) is a semi-synthetic derivative of podophyllotoxin extracted from plants. The mechanism of action differs from that of podophyllotoxin and common plant mites. It is characterized by not impeding collection of microtubules, and it is said to reversibly cleave single-stranded DNA depending on the amount of drug used. In addition, anti-tumor activity is exerted by terminating the S-G2 phase of the cell cycle irreversibly by blocking the ingestion of nucleosides. The clinical phase II trial was performed on oral and intravenous drugs and tested on lung cancer, testicular cancer, bladder cancer, prostate cancer, renal cancer, malignant lymphoma, and acute leukemia (AML). use