论文部分内容阅读
中国药典(90年版)二部共收载各类化学药物及其制剂967种,其中用非水碱量法进行含量测定的有125种,而用结晶紫作指示剂的有99种,可见非水碱量法在中国药典中是非常重要的方法。但结晶紫作为非水碱量法的指示剂时,因药物品种不同,终点颜色变化由紫到蓝或者由紫到绿,中间过渡色多,较难区别,不易掌握,在实际操作中往往造成误差。本文在盐酸苯海拉明非水碱量法滴定中用。α—萘酚苯甲醇作指示剂颜色变化明显,终点较易观察,并将滴定结果与药典法(90版),及电位法作对照。
The Chinese Pharmacopoeia (90-year edition), two were contained a total of 967 kinds of chemical drugs and their preparations, of which 125 were measured by the non-aqueous alkali method, and 99 were used as crystal violet indicator, Water and alkali method in the Chinese Pharmacopoeia is a very important method. However, when crystal violet is used as an indicator of the non-aqueous alkali method, it is hard to distinguish because of the different drug species, the end color change from purple to blue or purple to green, and the intermediate transition color is more difficult to grasp, which often results in the actual operation error. This article is used in diphenhydramine hydrochloride non-alkali volumetric titration. α-Naphthol benzyl alcohol as a indicator of significant color change, the end point easier to observe, and the titration results and the Pharmacopoeia (90th Edition), and the potential method as a control.