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目的:分析人类免疫缺陷病毒(HIV)感染者/艾滋病(AIDS)患者伴海洛因成瘾者(以下简称HIV/AIDS伴海洛因成瘾者)心理状况以及健康相关生命质量(health related quality of life,HRQOL)评分,并统计HRQOL的影响因素及影响因素主次关系。方法:使用抑郁自评量表(skelf-rating depression scale,SDS)评估HIV/AIDS伴海洛因成瘾患者心理状况,使用生活质量评价量表(short form 36 questionnaire,SF-36)测量HIV/AIDS伴海洛因成瘾患者的HRQOL评分,采用Pearson相关分析法分析HRQOL和SDS评分之间相关性,同时使用单因素方差分析及多元逐步线性回归统计对HRQOL的影响因素进行分析。结果:SDS评分结果显示抑郁症状109例(92.4%),其中轻度抑郁35例(29.6%),中度抑郁48例(40.6%),重度抑郁26例(22.2%)。平均HRQOL分数为(483.96±125.85)分,无症状HIV感染者HRQOL总分高于AIDS患者(P<0.05),且HRQOL与SDS评分呈负相关(R=-0.476,P=0.002)。统计结果显示锻炼、抗HIV治疗、年龄、机会感染、并发肿瘤、文化程度、婚姻状况、美沙酮治疗、居住地可影响HRQOL评分。其中HRQOL总分与年龄、机会感染、并发肿瘤、居住地因素呈负相关(P<0.05),与锻炼情况、抗HIV和美沙酮治疗、文化程度、婚姻状况因素呈现正相关(P<0.05)。结论:HIV/AIDS伴海洛因依赖者普遍伴有抑郁症状,HRQOL较差。在治疗中应重视大龄、低学历、农村居民、并发机会感染和肿瘤患者以及无配偶者的防治。
Objective: To analyze the psychological status and health-related quality of life (HRQOL) of HIV-infected persons / AIDS patients with heroin addicts (hereinafter referred to as HIV / AIDS with heroin addicts) ) Score, and statistics of HRQOL factors and influencing factors primary and secondary relationship. METHODS: Mental status of HIV / AIDS patients with heroin addiction was assessed using the skelf-rating depression scale (SDS), and HIV / AIDS patients were measured using the short form 36 questionnaire (SF-36) The HRQOL scores of heroin addicts were analyzed by Pearson correlation analysis between HRQOL and SDS scores. The influencing factors of HRQOL were analyzed by one-way ANOVA and multivariate stepwise linear regression. Results: SDS scores showed that 109 cases (92.4%) had depressive symptoms, including 35 cases (29.6%) of mild depression, 48 cases (40.6%) of moderate depression and 26 cases (22.2%) of severe depression. The average HRQOL score was (483.96 ± 125.85) points. The total score of HRQOL in asymptomatic HIV-infected patients was higher than that of AIDS patients (P <0.05). HRQOL was negatively correlated with SDS score (R = -0.476, P = 0.002). Statistics show that exercise, anti-HIV treatment, age, opportunistic infections, concurrent tumors, education, marital status, methadone treatment, and place of residence can affect HRQOL scores. The total score of HRQOL was negatively correlated with age, opportunistic infection, concurrent tumor and residence (P <0.05), and positive correlation with exercise, anti-HIV and methadone treatment, educational level and marital status (P <0.05). Conclusion: HIV / AIDS with heroin dependence are generally associated with depressive symptoms, HRQOL poor. In the treatment should pay attention to older, less educated, rural residents, opportunistic infections and cancer patients and control of unmarried persons.