In order to understand the chemical-biological interactions goving their activities toward neuraminidase (NA),QSAR models of 28 thiazolidine-4-carboxylic acid derivatives with inhibitory influenza A virus were developed.Here a quantitative structure activity relationship (QSAR) model was built by three-dimensional holographic atomic vector field (3D-HoVAIF) and multiple linear regression (MLR).The estimation stability and prediction ability of the model were strictly analyzed by both intal and extal validations.The correlation coefficient (R2) of established MLR model was 0.984,and the cross-validated correlation coefficient (Q2) of MLR model was 0.947.Furthermore,the cross-validated correlation coefficient for the test set (Qexl2) was 0.967.The binding mode patt of the compounds to the binding site of integrase enzyme was confirmed by docking studies.The results of present study indicated that this model can aid in designing more potent neuraminidase inhibitors.