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目的:探讨中国江西汉族人群ITGA2 C807T基因多态性与大肠腺瘤及大肠癌患病风险的关系.方法:本研究为基于医院人群的病例-对照研究,包括95例正常对照、48例大肠腺瘤和89例大肠癌个体.采用聚合酶链反应-限制性片段长度多态性(polymerase chain reaction restriction fragment length polymorphism assay,PCR-RFLP)方法检测研究人群ITGA2C807T基因型分布,并对该基因多态性与大肠癌临床病理特征的关系进行分析.结果:ITGA2 C807T基因型频率和等位基因频率在大肠腺瘤组和对照组的总体分布无显著差异,而其在大肠癌组和对照组的分布具有显著差异.相比于野生基因型CC,携带变异基因型(CT+TT)的个体患大肠腺瘤和大肠癌的风险均增高.在分层分析中,变异基因型并未增加患大肠腺瘤的风险,变异基因型增加患大肠癌的风险在女性、吸烟、饮酒、高学历、脑力劳动、城市受试者中具有统计学意义.大肠癌病例分别按病变部位、病理类型、肿瘤大小、分化程度、浸润深度、淋巴结转移和Dukes分期临床病理特征分层后,均未见ITGA2 C807T基因型分布存在显著性差异.结论:ITGA2 C807T基因多态性可能增加大肠腺瘤和大肠癌患病风险.
Objective: To investigate the association of ITGA2 C807T gene polymorphism with the risk of colorectal adenoma and colorectal cancer in Han population of Jiangxi province, China.Methods: This study was a case-control study based on hospital population, including 95 normal controls and 48 cases of colorectal gland Tumor and 89 individuals with colorectal cancer. The distribution of ITGA2C807T genotypes was examined by PCR-RFLP and the polymorphism of the gene Sex and colorectal cancer clinicopathological characteristics were analyzed.Results: ITGA2 C807T genotype frequency and allele frequency in the colorectal adenoma group and the control group, the overall distribution of no significant difference, and its distribution in the colorectal cancer group and the control group Were significantly higher in individuals carrying the variant genotype (CT + TT) than in the wild-type genotype CC In the stratified analysis, the variant genotype did not increase in patients with the large intestine gland The risk of neoplasia, variant genotype increased risk of colorectal cancer in women, smoking, drinking, highly educated, mental work, urban subjects with statistical significance. There were no significant differences in the distribution of ITGA2 C807T genotypes between the colorectal cancer cases and the pathological types, pathological types, tumor size, differentiation degree, depth of invasion, lymph node metastasis and Dukes staging.Conclusion: The ITGA2 C807T gene Polymorphism may increase the risk of colorectal adenoma and colorectal cancer.