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目的:探讨高压氧联合药物治疗脊柱术后谵妄的临床疗效。方法:选取2012年12月至2018年9月入住临沂市中心医院骨科的脊柱术后谵妄患者124例，依据患者或其家属的意愿分为高压氧加药物组和单纯药物组各62例。单纯药物组进行常规药物治疗，高压氧加药物组在常规药物治疗基础上增加高压氧治疗，2组治疗7 d后用简明精神病评定量表和临床总体印象量表评定临床疗效。结果:治疗前高压氧加药物组简明精神病评定量表、临床总体印象量表评分与单纯药物组比较差异无统计学意义(n P>0.05)。治疗7 d后高压氧加药物组简明精神病评定量表评分为(20.2±2.7)分，临床总体印象量表评分为(2.05±0.73)分，均明显低于单纯药物组[(29.7±4.7)分、(3.99±1.70)分]，差异均有统计学意义(n P0.05). After 7 days treatment, the BPRS (20.2±2.7) and CGIS (2.05±0.73) of experimental group were significantly lower than those of the control group (29.7±4.7 and 3.99±1.70); the difference between the two groups was statistically significant (n P<0.05).n Conclusion:HBO combined with medication in the treatment of postoperative delirium after spine surgery could better relieve clinical symptoms, therefore, improve patients′ life quality.