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目的 :比较苯那普利 ( BE)与氨氯地平 ( AM)对原发性高血压 ( EH)合并 β2 微球蛋白 ( β2 -MG)增高患者的降压作用 ,并评价药物对肾功能的影响.方法 :对 80例轻 -中度 EH并发β2 - MG增高患者采用随机单盲自身前后对照试验 ,观察给予 BE10~ 2 0 mg/ d或 AM5~ 10 mg/ d4周后的诊室血压 ( CBP)、动态血压 ( ABP)、血尿素氮、肌酐、尿酸、β2 - MG和白蛋白的变化.结果 :两药治疗后CBP明显降低 ( P 5 0%,但 AM降压作用优于 BE,BE组治疗后尿β2 - MG和白蛋白排泄减少 ( P“,”Objective:To compare the antihypertensive effects of amlodipine (AM) and benazepril (BE) in essential hypertensive (EH) patients with increased β 2 microglobulin (β 2 MG),and evaluate the effect of these drugs on the renal function.Method:Eighty minor to moderate EH patients with increased β 2 MG were selected.According to a random,single blind self controlled trail,patients received either AM 5~10 mg once daily or BE 10~20 mg once daily,each monotherapy for 4 weeks.Clinical blood pressure (CBP),ambulatory blood pressure (ABP),blood urine nitrogen,serum creatinine,uric acid,β 2 MG,and urine excretion of β 2 MG and albumin were measured at the end of 1 week placebo and after 4 week therapy,respectively.Result:CBP was significantly reduced with the use of both drugs (P< 0.01 ).However,ABP showed that once daily therapies with AM provided an antihypertensive effect that was superior to BE,though the tough to peak ratios of SBP and DBP for both drugs were more than 50%.Urine excretion of β 2 MG and albumin were decreased in BE group (P< 0.05 ).AM had no effect on the parameters in renal function.Conclusion:Antihypertensive action with AM is superior to BE,while BE is better in EH patients with renal impairment.