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目的探讨莆田地区慢性丙型肝炎患者血清自身抗体情况及临床意义。方法采集到医院就诊的186例丙型肝炎患者血清及50例健康体检者血清,检测自身抗体(ANA、ASA、ANCA、AMA-M2、抗LKM-1、抗LC-l、抗SLA/LP)的阳性率,比较自身抗体(+)及自身抗体(-)群病毒复制和肝功能状况。结果丙型肝炎患者自身抗体总阳性率为21.5%,高于正常对照组的3.7%(P<0.05);自身抗体以低滴度为主,多见抗核抗体。结论丙肝病毒在机体感染过程中可诱导自身免疫反应,使体内产生多种自身抗体,其检出率与肝脏损伤程度和病毒的复制水平有关。因此,监测丙肝患者血清中自身抗体对临床诊疗具有重要的指导意义。
Objective To investigate the serum autoantibodies in patients with chronic hepatitis C in Putian area and its clinical significance. Methods Serum samples of 186 patients with hepatitis C and 50 healthy controls were collected from hospital for detection of autoantibodies (ANA, ASA, ANCA, AMA-M2, anti-LKM-1, anti-LC- The positive rates of autoantibodies (+) and autoantibodies (-) were compared between viral replication and liver function status. Results The total positive rate of autoantibodies in patients with hepatitis C was 21.5%, which was higher than that in the control group (3.7%, P <0.05). The autoantibodies were mainly low titers and anti-nuclear antibodies were common. Conclusions Hepatitis C virus can induce autoimmune reaction in the process of body infection and produce a variety of autoantibodies in vivo. The detection rate is related to the degree of liver damage and the level of virus replication. Therefore, the monitoring of serum autoantibodies in patients with hepatitis C has an important guiding significance for clinical diagnosis and treatment.