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本文对5例胰腺癌患者的自身肿瘤组织行体外化疗药物敏感性检测,分析其实验结果与临床药物治疗的相关性。本文药敏预测提示,仅2例对氟脲嘧啶显示出很好的相关性。其余3例相关性较差。其敏感药依次是丝裂霉素、阿霉素、噻替哌。在药敏指导下化疗半年后随访,5例患者中有4例药物测定结果与临床效果一致,均已存活1年以上,治疗有效率达80％。作者认为:尤其对中晚期胰腺癌患者,在药敏指导下化疗可提高生存率。
In this paper, 5 cases of pancreatic cancer patients with self-tumor tissue in vitro chemotherapy drug sensitivity testing, analysis of its experimental results and clinical drug treatment. This drug susceptibility prediction suggests that only 2 cases showed a good correlation with fluorouracil. The remaining 3 cases had poor correlation. The sensitive drugs were mitomycin, doxorubicin and thiotepa. After half a year of follow-up chemotherapy after drug susceptibility, 4 of the 5 patients had the same results as the clinical results. All of them had survived for more than 1 year. The effective rate of treatment was 80%. The authors believe that: especially in patients with advanced pancreatic cancer, chemotherapy-guided chemotherapy can improve survival.