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用高脂血症造型后给药及正常小鼠给药分别研究了中药复方片剂益康灵对动物血脂的影响并做了毒性试验。结果表明:益康灵对高脂血症小鼠Tc的升高、HDL-c的降低有预防意义。对高脂血症大鼠可使Tc、TG及AI值降低,HDL-c升高。对正常小鼠血脂水平无明显影响。益康灵灌胃给药LD_(50)无法求出。提示益康灵对血脂水平有积极的影响且毒性甚微。
The effect of Yikangling, a Chinese medicine compound tablet, on blood lipids in animals was studied by means of post-administration hyperlipidemia modeling and normal mice administration and toxicity tests were conducted. The results showed that Yikangling has preventive significance for elevated Tc and reduced HDL-c in hyperlipidemic mice. The hyperlipidemic rats can reduce Tc, TG and AI values, and increase HDL-c. No significant effect on blood lipid levels in normal mice. Yi Kang Ling intragastric administration of LD_ (50) can not be found. It is suggested that Yikangling has a positive effect on blood lipid levels and has little toxicity.