论文部分内容阅读
[目的]观察参苓白术散对胃癌术后化疗患者生活质量及CD3~+和CD4~+细胞数量的影响。[方法]将75名胃癌患者随机分为治疗组(n=37)和对照组(n=38),治疗组在西医常规治疗的基础上予参苓白术散中药汤剂口服治疗,对照组采用西医常规治疗:手术+化疗。比较2组治疗前后QOL生活质量评分、CD3~+细胞数量和CD4~+细胞数量及II级以上毒副反应。[结果]2组治疗后的生活质量评分较治疗前有所升高(P<0.05),但是治疗组生活质量评分的改善程度较对照组高(P<0.05)。治疗组治疗前后CD3~+和CD4~+细胞数量差异有统计学意义(P<0.05),而对照组治疗前后CD3~+和CD4~+细胞数量差异无统计学意义(P>0.05),且治疗组治疗前后的CD3~+和CD4~+细胞数量的差值与对照组比较差异有统计学意义(P<0.05)。治疗组和对照组在白细胞下降、血小板、血红蛋白下降等II及以上的毒副反应差异无统计学意义(P>0.05)。在II级以上胃肠道毒副反应方面差异有统计学意义(P<0.05)。[结论]参苓白术散能有效的改善胃癌术后化疗患者的生活质量,提高患者CD3~+和CD4~+细胞数量,并且能降低化疗过程中出现的胃肠道不良反应。
[Objective] To observe the effect of Shenling Baizhu San on the quality of life and the number of CD3 ~ + and CD4 ~ + cells in patients with gastric cancer after chemotherapy. [Methods] 75 gastric cancer patients were randomly divided into treatment group (n = 37) and control group (n = 38). The treatment group was given oral administration of traditional Chinese medicine and decoction of traditional Chinese medicine on the basis of conventional treatment. Western conventional treatment: surgery + chemotherapy. The QOL quality of life, the number of CD3 ~ + cells, the number of CD4 ~ + cells and the grade II toxicities were compared before and after treatment. [Results] The quality of life scores of the two groups after treatment were higher than those before treatment (P <0.05), but the quality of life in the treatment group improved more than the control group (P <0.05). There were significant differences in the number of CD3 ~ + and CD4 ~ + cells in the treatment group before and after treatment (P <0.05), while there was no significant difference in the number of CD3 ~ + and CD4 ~ + cells before and after treatment The difference between the number of CD3 ~ + and CD4 ~ + cells in the treatment group before and after treatment was statistically significant (P <0.05). There were no significant differences in the toxicity of II and above in the treatment group and the control group between leukopenia and thrombocytopenia and hemoglobin (P> 0.05). There was significant difference in gastrointestinal side effects above Grade II (P <0.05). [Conclusion] Shenling Baizhu Powder can effectively improve the quality of life of postoperative chemotherapy patients with gastric cancer, increase the number of CD3 ~ + and CD4 ~ + cells in patients with gastric cancer, and can reduce gastrointestinal adverse reactions during chemotherapy.