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对白人和黑人 IDDM 病人中Ⅱ级 HLA 的 DN-A 顺序分析表明 DQβ链在57位点的氨基酸(天门冬氨酸 Asp57)保证其不患 IDDM。与之对照,大多数日本 IDDM 病人存在 Asp-57阳性等位基因。为确定差异的原因和日本人中连接致糖尿病基因的 HLA 部分,作者用聚合酶链反应(PCR)结合限制性片段长度多态性(RFLP)分析法研究日
The DN-A sequence analysis of grade II HLA in white and black IDDM patients showed that the DQβ chain at position 57 (aspartate Asp57) ensured that it had no IDDM. In contrast, most Japanese IDDM patients have Asp-57 positive alleles. To determine the cause of the discrepancy and HLA-linked HLA-causing genes in Japanese, the authors used polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP)