近年来由于口服避孕药(OC)与其它药物并用致使避孕失败报道不断增加,其相互作用机理可认为:(1) 降低了甾体激素自肠内吸收与再吸收的量;(2) 甾体避孕药的血浆蛋白结合量增加,生成无生物活性的物质;(3) 甾体避孕药从其受体部位被取代;(4) 避孕药物尿中排泄量增加;(5) 促进避孕药在肝内降解。本文就与OC并用可致避孕失败的药物分 In recent years, oral contraceptives (OC) combined with other drugs led to increasing contraceptive coverage, the interaction mechanism can be considered: (1) reduced the amount of steroid hormone absorption and reabsorption from the intestine; (2) steroids Contraceptives increase the amount of plasma protein binding, resulting in non-bioactive substances; (3) steroidal contraceptives are replaced from their receptor sites; (4) contraceptives urinary excretion increased; (5) to promote contraceptives in the liver Internal degradation. This article on the use of OC and can cause contraceptive failure points