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目的通过观察不协调同源基因5B(Unc5B)蛋白在肾透明细胞癌(RCCC)组织中的表达情况,探求其作为RCCC新的肿瘤标记物和治疗靶点的临床意义。方法 2007年6月至2012年6月经手术切除并经病理诊断明确的48例RCCC患者(男26例,女22例),所有患者均为首次发病,手术前未经过放化疗及生物治疗。对患者手术切除的癌组织及癌旁非癌组织标本,采用免疫组织化学SP法检测Unc5B的表达水平。结果 Unc5B在RCCC癌旁正常肾组织中及RCCC组织中均有表达,但在癌旁正常肾组织中Unc5B++~+++的阳性表达率明显高于RCCC组织,差异有统计学意义(75.0%vs 16.7%,P<0.01)。结论 Unc5B的较低表达与RCCC相关,可为临床诊断提供帮助,并有望成为RCCC治疗的靶标。
OBJECTIVE: To investigate the clinical significance of Unc5B protein expression in renal clear cell carcinoma (RCCC) tissues as a novel tumor marker and therapeutic target for RCCC. Methods From June 2007 to June 2012, 48 patients with RCCC (26 males and 22 females) were surgically excised and pathologically diagnosed. All patients were the first to have an episode without radiochemotherapy and biotherapy before surgery. Surgical resection of patients with cancer tissues and adjacent non-cancerous tissue specimens using immunohistochemical SP method Unc5B expression levels. Results Unc5B was detected both in normal renal tissues adjacent to RCCC and in RCCC tissues. However, the positive rate of Unc5B ++ ~ +++ in adjacent normal tissues was significantly higher than that in RCCC tissues (75.0% vs 16.7%, P <0.01). Conclusion The lower expression of Unc5B is associated with RCCC, which may be helpful in clinical diagnosis and is expected to be the target of RCCC therapy.